The PiPA group is a multidisciplinary team based in the Department of Paediatrics and Nuffield Department of Clinical Neurosciences at the University of Oxford. We are interested in the development of human pain processing, with a particular focus on improving clinical care and treatment of neonatal, infant and childhood pain.
The Poppi Trial officially launched on the 15th September, and recruitment is now underway! The trial will take place over 3 years and aims to recruit 156 infants. It is a single centre randomised placebo-controlled trial investigating the efficacy of morphine analgesia for procedural pain in infants. The protocol was published in the Lancet and can… Continue reading Poppi Trial Launch!
A new publication for the PiPA Group! Citation: Goksan S, Hartley C, Hurley SA, Winkler AM, Duff EP, Jenkinson M, Rogers R, Clare S, Slater R (2016) Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation. Magnetic Resonance in Medicine. [epub ahead of print Abstract: Purpose: Blood oxygen level dependent (BOLD) brain activity, measured using functional MRI (fMRI),… Continue reading Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation
A new publication for the PiPA group! Citation: Hartley C, Moultrie F, Gursul D, Hoskin A, Adams E, Rogers R, Slater R. (2016) Changing Balance of Spinal Cord Excitability and Nociceptive Brain Activity in Early Human Development. Current Biology. [In press] Abstract: In adults, nociceptive reflexes and behavioral responses are modulated by a network of brain regions via… Continue reading Changing Balance of Spinal Cord Excitability and Nociceptive Brain Activity in Early Human Development
A new publication for the PiPA group! Citation: Pillai Riddell R, Fitzgerald M, Slater R, Stevens B, Johnston C, Campbell-Yeo M. (2016) Using only behaviours to assess infant pain: a painful compromise? Pain. 2016 Jun 8. [Epub ahead of print] Abstract: In this issue of PAIN®, Valitalo and colleagues’ report on an Item Response Theory analysis examining… Continue reading Using only behaviours to assess infant pain: a painful compromise?
We are going to begin recruitment for the Poppi trial soon. Poppi is a randomised controlled trial investigating the use of morphine as an analgesic for procedural pain in infants. The protocol for the trial has been published in The Lancet and can be viewed here: Hartley C, Moultrie F, Juszczak E, Adams E & Slater R. (2016) Protocol… Continue reading The Poppi Trial – Protocol Publication
A new publication for the PiPA group! Citation: Poorun R, Hartley C, Goksan S, Worley A, Boyd S, Cornelissen L, Berde C, Rogers R, Ali T, Slater R.(2015) Electroencephalography during general anaesthesia differs between term-born and premature-born children. Clin Neurophysiol. doi: 10.1016/j.clinph.2015.10.041. [Epub ahead of print] Abstract: Objectives: Premature birth is associated with a wide range of… Continue reading Electroencephalography During General Anaesthesia Differs Between Term-Born and Premature-Born Children.
A new publication for the PiPA group! Citation: Hartley C, Goksan S, Poorun R, Brotherhood K, Mellado GS, Moultrie F, Rogers R, Adams E, Slater R. (2015) The relationship between nociceptive brain activity, spinal reflex withdrawal and behaviour in newborn infants. Sci Rep. 5:12519. doi: 10.1038/srep12519. Abstract: Measuring infant pain is complicated by their inability to describe… Continue reading The Relationship Between Nociceptive Brain Activity, Spinal Reflex Withdrawal and Behaviour in Newborn Infants