welcome

Welcome to Our Group!

The PiPA group is a multidisciplinary team based in the Department of Paediatrics and  Nuffield Department of Clinical Neurosciences at the University of Oxford. We are interested in the development of human pain processing, with a particular focus on improving clinical care and treatment of neonatal, infant and childhood pain. Advertisements

Uncategorized

Nociceptive brain activity as a measure of analgesic efficacy in infants

A new publication for the PiPA Group! Citation: Hartley C, Duff EP, Green G, Mellado GS, Worley A, Rogers R, Slater R (2017) Nociceptive brain activity as a measure of analgesic efficacy in infants. Science Translational Medicine. 3;9(388) Abstract: In the medical setting, infants and young children are often subjected to painful procedures requiring pain relief. However, the infants… Continue reading Nociceptive brain activity as a measure of analgesic efficacy in infants

publications

Improving the Treatment of Infant Pain

A new publication for the PiPA Group! Citation: Moultrie F, Slater R, Hartley C (2017) Improving the treatment of infant pain Current Opinion in Supportive and Palliative Care. Jun;11(2):112-117 Abstract: Purpose of review: Pain management presents a major challenge in neonatal care. Newborn infants who require medical treatment can undergo frequent invasive procedures during a critical period of neurodevelopment. However,… Continue reading Improving the Treatment of Infant Pain

Uncategorized

A blinded randomised placebo-controlled trial investigating the efficacy of morphine analgesia for procedural pain in infants: Trial protocol

A new publication for the PiPA Group! Citation: Slater R, Hartley 1, Moultrie F, Adams E, Juszczak E, Rogers R, Norman JE, Patel C, Stanbury K, Hoskin A, Green G, Poppi Trial Team (2016) A blinded randomised placebo-controlled trial investigating the efficacy of morphine analgesia for procedural pain in infants: Trial protocol. Wellcome Open Research. Abstract: Infant pain has both immediate and long-term negative consequences, yet in clinical practice it is… Continue reading A blinded randomised placebo-controlled trial investigating the efficacy of morphine analgesia for procedural pain in infants: Trial protocol

publications

Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation

A new publication for the PiPA Group! Citation: Goksan S, Hartley C, Hurley SA, Winkler AM, Duff EP, Jenkinson M, Rogers R, Clare S, Slater R (2016) Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation. Magnetic Resonance in Medicine. [epub ahead of print Abstract: Purpose: Blood oxygen level dependent (BOLD) brain activity, measured using functional MRI (fMRI),… Continue reading Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation

publications

Changing Balance of Spinal Cord Excitability and Nociceptive Brain Activity in Early Human Development

A new publication for the PiPA group! Citation: Hartley C, Moultrie F, Gursul D, Hoskin A, Adams E, Rogers R, Slater R. (2016) Changing Balance of Spinal Cord Excitability and Nociceptive Brain Activity in Early Human Development. Current Biology. [In press] Abstract: In adults, nociceptive reflexes and behavioral responses are modulated by a network of brain regions via… Continue reading Changing Balance of Spinal Cord Excitability and Nociceptive Brain Activity in Early Human Development