Electroencephalography During General Anaesthesia Differs Between Term-Born and Premature-Born Children.

A new publication for the PiPA group!


Poorun R, Hartley C, Goksan S, Worley A, Boyd S, Cornelissen L, Berde C, Rogers R, Ali T, Slater R.(2015) Electroencephalography during general anaesthesia differs between term-born and premature-born children. Clin Neurophysioldoi: 10.1016/j.clinph.2015.10.041. [Epub ahead of print]



Objectives: Premature birth is associated with a wide range of complications in later life, including structural and functional neurological abnormalities and altered pain sensitivity. We investigated whether during anaesthesia premature-born children display different patterns of background EEG activity and exhibit increased responses to nociceptive stimuli.

Methods: We examined background EEG and time-locked responses to clinical cannulation in 45 children (mean age (±SD) at study: 4.9(±3.0)years) under sevoflurane monoanaesthesia maintained at a steady-state end-tidal concentration of 2.5%. 15 were born prematurely (mean gestational age at birth: 29.2±3.9weeks) and 30 were age-matched term-born children.

Results: Background levels of alpha and beta power were significantly lower in the premature-born children compared to term-born controls (p=0.048). Clinical cannulation evoked a significant increase in delta activity (p=0.032), which was not significantly different between the two groups (p=0.44).

Conclusions: The results indicate that whilst under anaesthesia premature-born children display different patterns of background brain activity compared to term-born children.

Significance: As electrophysiological techniques are increasingly used by anaesthetists to gauge anaesthetic depth, differences in background levels of electrophysiological brain activity between premature and term-born children may be relevant when considering titration of anaesthetic dose.


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